Vascular stabilization by angiopoietin-1
نویسندگان
چکیده
منابع مشابه
PTK7+ Mononuclear Cells Express VEGFR2 and Contribute to Vascular Stabilization by Upregulating Angiopoietin-1.
OBJECTIVE In angiogenesis, circulating mononuclear cells are recruited to vascular lesions; however, the underlying mechanisms are poorly understood. APPROACH AND RESULTS Here, we characterize the functional role of protein tyrosine kinase 7 (PTK7)-expressing CD11b(+) mononuclear cells in vitro and in vivo using a mouse model of angiogenesis. Although the frequencies of PTK7(+)CD11b(+) cells ...
متن کاملHypertension, Vascular Rarefaction and Angiopoietin-1
Hypertension is a very common but incompletely understood disease, especially in its pathogenesis and vascular complications occurring in the cardiovascular research filed. There are many explanations for pathological mechanisms in hypertension, including adrenergic over-reactivity, renin-angiotensin-aldosteron system abnormality and constitutionalgenetic-environmental factors. Recently emergin...
متن کاملPTK7+Mononuclear Cells Express VEGFR2 and Contribute to Vascular Stabilization by Upregulating Angiopoietin-1Significance
Objective—In angiogenesis, circulating mononuclear cells are recruited to vascular lesions; however, the underlying mechanisms are poorly understood. Approach and Results—Here, we characterize the functional role of protein tyrosine kinase 7 (PTK7)-expressing CD11b+ mononuclear cells in vitro and in vivo using a mouse model of angiogenesis. While the frequencies of PTK7+CD11b+ cells in the bone...
متن کاملPlasma angiopoietin-1, angiopoietin-2, angiopoietin receptor tie-2, and vascular endothelial growth factor levels in acute coronary syndromes.
BACKGROUND Angiopoietin (Ang) -1 and -2, their receptor Tie-2, and vascular endothelial growth factor (VEGF) regulate angiogenesis and may be important in myocardial collateral development. Elevated levels of growth factors and their receptors are reported in myocardial infarction (MI), but changes after an acute coronary event are unknown. METHODS AND RESULTS Plasma Ang-1, Ang-2, Tie-2, and ...
متن کاملSignaling and functions of angiopoietin-1 in vascular protection.
Angiopoietin-1 (Ang1) has powerful vascular protective effects: suppressing plasma leakage, inhibiting vascular inflammation, and preventing endothelial death. Preclinical studies indicate that Ang1 may be therapeutically useful in a number of situations, including treatment of edema, endotoxemia, and transplant arteriosclerosis. However, the ligand has also been implicated in vessel remodeling...
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ژورنال
عنوان ژورنال: Folia Pharmacologica Japonica
سال: 2010
ISSN: 0015-5691,1347-8397
DOI: 10.1254/fpj.136.26